Activation and regulation


Claire Harris, Mihály Józsi

There will be a brief introduction to the session, after which students will be split into 4 discussion groups; each group will focus on one paper as detailed below. 4 or 5 discussion points will be given to each group and the tutors will join the students with these discussions.  Students should be very familiar with the paper that they are set before the day, so that they can contribute to the discussion with full knowledge.


1. Sjöberg AP, Trouw LA, Blom AM

Complement activation and inhibition: a delicate balance.

Trends Immunol. 2009 Feb;30(2):83-90. Epub 2009 Jan 12.

2. Katschke KJ Jr, Stawicki S, Yin J, Steffek M, Xi H, Sturgeon L, Hass PE, Loyet KM, Deforge L, Wu Y, van Lookeren Campagne M, Wiesmann C.

Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement.

J Biol Chem. 2009 Apr 17;284(16):10473-9. Epub 2009 Feb 5.

3. Spitzer D, Mitchell LM, Atkinson JP, Hourcade DE.

Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assembly.

J Immunol. 2007 Aug 15;179(4):2600-8.

4. Wu J, Wu YQ, Ricklin D, Janssen BJ, Lambris JD, Gros P.

Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.

Nat Immunol. 2009 Jul;10(7):728-33. Epub 2009 Jun 7.