Therapeutical approaches

 

Reading materials:

Tom E. Mollnes, Michael Kirschfink:
Strategies of therapeutic complement inhibition

Daniel Ricklin & John D Lambris:
Complement-targeted therapeutics

    Basta M. presentations:

  1. Basta M. et al. Mechanism fo therapeutic effect of high-dose intravenous immunoglobulin. Attenuation of acute, complement-mediated immune damage in a guinea pig model. J Clin Invest.1989; 84:1974-81.
  2. Basta M. et al. F(ab)’2 – mediated neutralization of C3a and C5a anaphylatoxins: a novel effector function of immunoglobulins. Nat Med 2003: 9:431-8.
  3. Arumugam TV et al. Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death. PNAS 2007: 104:14104-14109.