Factor H-related diseases and animal models
Plan of session:
1) RECOMMENDED READING PRIOR TO SESSION:
Students to have read the following two manuscripts in order that they understand the background of factor H and human disease
Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H.
de Córdoba SR, de Jorge EG.
Clin Exp Immunol. 2008 Jan;151(1):1-13.weblink to article
Factor H related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation.
Heinen S, Hartmann A, Lauer N, Wiehl U, Dahse HM, Schirmer S, Gropp K, Enghardt T, Wallich R, Halbich S, Mihlan M, Schlotzer-Schrehardt U, Zipfel PF, Skerka C.
Blood. 2009 Jun 15.
weblink to article
2) SESSION OVERVIEW:
Introduction: advantages and limitations of in vitro and of animal models for complement research
5 minutes PZ
Overview of the animal models of FH-related disease 10 minutes MP
Interactive discussion 60 minutes MP / PZ