Inflammatory and autoimmune disorders

Session organizers: prof. Anna Blom and prof. Moh Daha

anna.blom@med.lu.se

M.R.Daha@lumc.nl

 

Objectives:

- to understand role ole of complement in recognitions and clearance of apoptotic and necrotic cells

- Which complement molecules recognize dying cells

- What are the effects of complement deficiencies in patients and animal models with regard to cell death and autoimmunity

- Implications to autoimmunity and diseases such as SLE (systemic lupus erythematosus)

- How to design good experiments on the subject

 

Pre-session required reading:

C4b-binding protein and factor H compensate for the loss of membrane-bound complement inhibitors to protect apoptotic cells against excessive complement attack.

Trouw LA, Bengtsson AA, Gelderman KA, Dahlbäck B, Sturfelt G, Blom AM. J Biol Chem. 2007 Sep 28;282(39):28540-8.

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies.

Botto M, Dell'Agnola C, Bygrave AE, Thompson EM, Cook HT, Petry F, Loos M, Pandolfi PP, Walport MJ. Nat Genet. 1998 May;19(1):56-9.

It is absolutely necessary to read the listed papers before coming to Budapest as they will form crucial basis for our discussions.

 

Session format:

The session will start with a 15 min devoted to writing down questions on the broadly understood subject of autoimmunity and complement that occurred to participants during reading of the two papers.

Every participant will be asked to write down at least three such questions.

The session will continue with a very brief introduction of the subject by Anna and Moha (15 min) followed by discussion based on the questions prepared by the participants.

Please prepare your 3 questions before coming to Budapest.